SMTL ID : 4fqz.1

Crystal structure of a protease-resistant mutant form of human galectin-8

Coordinates

PDB Format

Method

X-RAY DIFFRACTION 2.80 Å

Oligo State

monomer

Ligands

1 x BGC- GAL: beta-D-galactopyranose-(1-4)-beta-D-glucopyranose(Non-covalent)

BGC-GAL.1: 7 residues within 4Å: Chain A: R.45, H.65, N.67, R.69, N.79, W.86, E.89 5 PLIP interactions: 5 interactions with chain A Hydrogen bonds: A:R.69, A:R.69, A:R.45, A:R.45, A:N.67, A:R.69, A:N.79

10 x EDO: 1,2-ETHANEDIOL(Non-covalent)(Non-functional Binders)

EDO.2: 5 residues within 4Å: Chain A: E.90, L.125, Y.126, G.127 Ligands: EDO.4 2 PLIP interactions: 2 interactions with chain A Hydrogen bonds: A:E.90, A:G.127 EDO.3: 8 residues within 4Å: Chain A: I.76, C.78, E.90, I.91, T.92, L.124, L.125, Y.126 3 PLIP interactions: 3 interactions with chain A Hydrogen bonds: A:I.76, A:E.90, A:L.125 EDO.4: 4 residues within 4Å: Chain A: T.92, L.124, L.125 Ligands: EDO.2 3 PLIP interactions: 3 interactions with chain A Hydrogen bonds: A:T.92, A:T.92, A:L.125 EDO.5: 5 residues within 4Å: Chain A: A.73, G.74, Y.93, D.94, T.95 3 PLIP interactions: 3 interactions with chain A Hydrogen bonds: A:G.74, A:D.94, A:T.95 EDO.6: 7 residues within 4Å: Chain A: M.1, V.106, M.108, Q.115, V.116, A.117, H.122 3 PLIP interactions: 3 interactions with chain A Hydrogen bonds: A:V.106, A:Q.115, A:A.117 EDO.7: 4 residues within 4Å: Chain A: K.269, E.270, L.271, S.272 3 PLIP interactions: 3 interactions with chain A Hydrogen bonds: A:L.271, A:S.272, A:S.272 EDO.8: 4 residues within 4Å: Chain A: E.226, E.227, R.228, N.229 4 PLIP interactions: 4 interactions with chain A Hydrogen bonds: A:E.227, A:R.228, A:N.229, A:N.229 EDO.9: 3 residues within 4Å: Chain A: L.159, N.280, G.281 2 PLIP interactions: 2 interactions with chain A Hydrogen bonds: A:L.159, A:N.280 EDO.10: 7 residues within 4Å: Chain A: A.201, S.217, F.252, H.266, R.267, F.268, L.271 4 PLIP interactions: 4 interactions with chain A Hydrogen bonds: A:S.217, A:S.217, A:R.267, A:F.268 EDO.11: 3 residues within 4Å: Chain A: V.20, G.21, T.22 1 PLIP interactions: 1 interactions with chain A Hydrogen bonds: A:T.22

Links

RCSB   PDBe   PDBj   PDBsum   CATH   PLIP

Citation

Yoshida, H. et al., X-ray structure of a protease-resistant mutant form of human galectin-8 with two carbohydrate recognition domains. Febs J. (2012)

Release Date

2012-07-11

Peptides

Galectin-8: A

SMTL:PDB

SMTL Chain Id:
PDB Chain Id:

A
A

Galectin-8

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