SMTL ID : 4bmb.1

Crystal structure of the N terminal domain of human Galectin 8

Coordinates

PDB Format

Method

X-RAY DIFFRACTION 1.35 Å

Oligo State

monomer

Ligands

1 x BGC- GAL: beta-D-galactopyranose-(1-4)-beta-D-glucopyranose(Non-covalent)

BGC-GAL.1: 9 residues within 4Å: Chain A: R.42, H.62, N.64, R.66, V.74, N.76, W.83, E.86 Ligands: NA.3 6 PLIP interactions: 6 interactions with chain A Hydrogen bonds: A:R.66, A:R.66, A:R.42, A:R.42, A:R.66, A:N.76, A:E.86 Water bridges: A:E.86, A:E.86, A:R.56

1 x ZN: ZINC ION(Non-covalent)

ZN.2: 3 residues within 4Å: Chain A: H.35, S.99, H.144 4 PLIP interactions: 2 interactions with chain A, 2 Ligand-Water interactions Metal complexes: A:H.35, A:H.144, H2O.4, H2O.4

1 x NA: SODIUM ION(Non-functional Binders)

NA.3: 4 residues within 4Å: Chain A: Q.44, R.56, W.83 Ligands: BGC-GAL.1 5 PLIP interactions: 5 interactions with chain A Hydrogen bonds: A:Q.44, A:Q.44, A:R.56, A:R.56 Water bridges: A:R.42

1 x GOL: GLYCEROL(Non-functional Binders)

GOL.4: 3 residues within 4Å: Chain A: Q.44, R.56, Y.138 2 PLIP interactions: 2 interactions with chain A Water bridges: A:Q.44, A:Y.138

Links

RCSB   PDBe   PDBj   PDBsum   CATH   PLIP

Citation

Ruiz, F.M. et al., Natural Single Amino Acid Polymorphism (F19Y) in Human Galectin-8: Detection of Structural Alterations and Increased Growth-Regulatory Activity on Tumor Cells. FEBS J. (2014)

Release Date

2014-03-19

Peptides

GALECTIN-8: A

SMTL:PDB

SMTL Chain Id:
PDB Chain Id:

A
A

GALECTIN-8