SMTL ID : 4bh1.1

H5 (tyTy) Influenza Virus Haemagglutinin in Complex with Avian Receptor Analogue 3'-SLN

Coordinates

PDB Format

Method

X-RAY DIFFRACTION 2.15 Å

Oligo State

hetero-3-3-mer

Ligands

3 x NAG- GAL- SIA: N-acetyl-alpha-neuraminic acid-(2-3)-beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose(Post Translational Modification)(Non-functional Binders)

NAG-GAL-SIA.1: 13 residues within 4Å: Chain A: Y.91, A.129, G.130, V.131, S.132, S.133, W.149, H.179, N.182, E.186, L.190, Q.222, G.224 10 PLIP interactions: 10 interactions with chain A Hydrogen bonds: A:Q.222, A:Q.222, A:Y.91, A:V.131, A:S.133, A:H.179, A:N.182, A:Q.222, A:Q.222 Water bridges: A:N.182, A:N.182, A:S.133, A:G.224 Hydrophobic interactions: A:W.149 NAG-GAL-SIA.2: 14 residues within 4Å: Chain C: Y.91, A.129, G.130, V.131, S.132, S.133, W.149, I.151, H.179, N.182, E.186, L.190, Q.222, G.224 9 PLIP interactions: 9 interactions with chain C Hydrogen bonds: C:Q.222, C:Q.222, C:Y.91, C:V.131, C:S.133, C:H.179, C:Q.222 Water bridges: C:N.182, C:N.182, C:S.133, C:G.224 Hydrophobic interactions: C:W.149, C:I.151 NAG-GAL-SIA.3: 13 residues within 4Å: Chain E: Y.91, A.129, G.130, V.131, S.132, S.133, W.149, H.179, N.182, E.186, L.190, Q.222, G.224 7 PLIP interactions: 7 interactions with chain E Hydrogen bonds: E:Q.222, E:Q.222, E:V.131, E:S.133, E:H.179, E:N.182, E:Q.222 Water bridges: E:N.182, E:N.182, E:S.133, E:G.224

3 x NAG: 2-acetamido-2-deoxy-beta-D-glucopyranose(Non-functional Binders)

NAG.4: 5 residues within 4Å: Chain A: N.165, N.236, D.237, A.238 Chain E: S.217 3 PLIP interactions: 3 interactions with chain A Hydrophobic interactions: A:A.238 Hydrogen bonds: A:N.165, A:N.236 NAG.7: 5 residues within 4Å: Chain A: S.217 Chain C: N.165, N.236, D.237, A.238 4 PLIP interactions: 4 interactions with chain C Hydrophobic interactions: C:A.238 Hydrogen bonds: C:N.165, C:N.236, C:N.236 NAG.9: 5 residues within 4Å: Chain C: S.217 Chain E: N.165, N.236, D.237, A.238 3 PLIP interactions: 3 interactions with chain E Hydrophobic interactions: E:A.238 Hydrogen bonds: E:N.165, E:N.236

4 x PO4: PHOSPHATE ION(Post Translational Modification)(Non-functional Binders)

PO4.5: 5 residues within 4Å: Chain A: A.58, D.88, L.89, F.95, Y.98 1 PLIP interactions: 1 interactions with chain A Hydrogen bonds: A:F.95 PO4.6: 6 residues within 4Å: Chain A: S.121, W.122, S.123, D.124, H.125, R.162 7 PLIP interactions: 7 interactions with chain A Hydrogen bonds: A:S.123, A:S.123, A:D.124, A:D.124, A:H.125 Salt bridges: A:H.125, A:R.162 PO4.8: 6 residues within 4Å: Chain C: S.121, W.122, S.123, D.124, H.125, R.162 7 PLIP interactions: 7 interactions with chain C Hydrogen bonds: C:S.121, C:S.123, C:S.123, C:D.124, C:H.125 Salt bridges: C:H.125, C:R.162 PO4.10: 6 residues within 4Å: Chain E: S.121, W.122, S.123, D.124, H.125, R.162 5 PLIP interactions: 5 interactions with chain E Hydrogen bonds: E:S.123, E:D.124, E:H.125 Salt bridges: E:H.125, E:R.162

Links

RCSB   PDBe   PDBj   PDBsum   CATH   PLIP

Citation

Xiong, X. et al., Receptor Binding by a Ferret-Transmissible H5 Avian Influenza Virus. Nature (2013)

Release Date

2013-04-24

Peptides

HEMAGGLUTININ: ACE
HEMAGGLUTININ: BDF

SMTL:PDB

SMTL Chain Id:
PDB Chain Id:

A
A

C
C

E
E

B
B

D
D

F
F

HEMAGGLUTININ

HEMAGGLUTININ

Related Entries With Identical Sequence