SMTL ID : 3vkl.1 (1 other biounit)

Protease-resistant mutant form of human Galectin-8 in complex with two lactose molecules

Coordinates

PDB Format

Method

X-RAY DIFFRACTION 2.55 Å

Oligo State

monomer

Ligands

2 x BGC- GAL: beta-D-galactopyranose-(1-4)-beta-D-glucopyranose(Non-covalent)

BGC-GAL.1: 7 residues within 4Å: Chain A: R.45, H.65, N.67, R.69, N.79, W.86, E.89 6 PLIP interactions: 6 interactions with chain A Hydrogen bonds: A:R.69, A:R.69, A:R.45, A:R.45, A:N.67, A:R.69, A:N.79 Water bridges: A:R.59 BGC-GAL.2: 8 residues within 4Å: Chain A: H.203, N.205, R.207, V.214, N.216, W.223, E.226, R.228 2 PLIP interactions: 2 interactions with chain A Hydrogen bonds: A:R.207, A:R.207, A:R.228, A:H.203, A:R.207

12 x EDO: 1,2-ETHANEDIOL(Non-covalent)(Non-functional Binders)

EDO.3: 5 residues within 4Å: Chain A: R.45, F.46, Q.47, N.67, G.142 5 PLIP interactions: 5 interactions with chain A Hydrogen bonds: A:R.45, A:Q.47, A:N.67 Water bridges: A:R.45, A:K.143 EDO.4: 3 residues within 4Å: Chain A: Q.115, A.117, H.122 4 PLIP interactions: 4 interactions with chain A Hydrogen bonds: A:Q.115, A:H.122 Water bridges: A:Q.115, A:A.117 EDO.5: 4 residues within 4Å: Chain A: E.90, L.125, Y.126, G.127 4 PLIP interactions: 4 interactions with chain A Hydrogen bonds: A:R.88, A:E.90, A:G.127 Water bridges: A:R.129 EDO.6: 2 residues within 4Å: Chain A: K.211, F.233 1 PLIP interactions: 1 interactions with chain A Hydrogen bonds: A:K.211 EDO.7: 5 residues within 4Å: Chain A: S.4, L.8, I.11, R.36, E.104 No protein-ligand interaction detected (PLIP) EDO.8: 3 residues within 4Å: Chain A: E.227, R.228, N.229 2 PLIP interactions: 2 interactions with chain A Hydrogen bonds: A:R.228, A:N.229 EDO.9: 4 residues within 4Å: Chain A: D.44, R.69, F.70, K.71 1 PLIP interactions: 1 interactions with chain A Hydrogen bonds: A:D.44 EDO.10: 3 residues within 4Å: Chain A: K.71, R.72, A.73 3 PLIP interactions: 3 interactions with chain A Hydrogen bonds: A:A.73 Water bridges: A:K.71, A:R.72 EDO.11: 4 residues within 4Å: Chain A: S.102, F.103, E.104, N.119 No protein-ligand interaction detected (PLIP) EDO.12: 7 residues within 4Å: Chain A: V.20, Q.51, S.54, S.55, R.59, A.60, Y.141 3 PLIP interactions: 3 interactions with chain A Hydrogen bonds: A:Q.51, A:A.60, A:Y.141 EDO.13: 4 residues within 4Å: Chain A: G.30, L.32, M.108 Ligands: EDO.14 1 PLIP interactions: 1 interactions with chain A Hydrogen bonds: A:G.30 EDO.14: 4 residues within 4Å: Chain A: N.7, E.287, R.289 Ligands: EDO.13 1 PLIP interactions: 1 interactions with chain A Hydrogen bonds: A:R.289

Links

RCSB   PDBe   PDBj   PDBsum   CATH   PLIP

Citation

Yoshida, H. et al., X-ray structure of a protease-resistant mutant form of human galectin-8 with two carbohydrate recognition domains. Febs J. (2012)

Release Date

2012-09-12

Peptides

Galectin-8: A

SMTL:PDB

SMTL Chain Id:
PDB Chain Id:

A
A

Galectin-8

Related Entries With Identical Sequence