SMTL ID : 3m3q.1

Crystal Structure of Agrocybe aegerita lectin AAL complexed with Ganglosides GM1 pentasaccharide

Coordinates

PDB Format

Method

X-RAY DIFFRACTION 2.20 Å

Oligo State

homo-dimer

Ligands

2 x BGC- GAL- NGA- GAL- SIA: beta-D-galactopyranose-(1-3)-2-acetamido-2-deoxy-beta-D-galactopyranose-(1-4)-[N-acetyl-alpha-neuraminic acid-(2-3)]beta-D-galactopyranose-(1-4)-beta-D-glucopyranose(Non-covalent)

BGC-GAL-NGA-GAL-SIA.1: 8 residues within 4Å: Chain A: P.43, N.44, H.60, R.64, N.73, W.81, E.84, R.86 3 PLIP interactions: 3 interactions with chain A Hydrogen bonds: A:N.44, A:R.64, A:N.73, A:R.64, A:R.64, A:R.86 BGC-GAL-NGA-GAL-SIA.2: 8 residues within 4Å: Chain B: P.43, N.44, H.60, R.64, N.73, W.81, E.84, R.86 3 PLIP interactions: 3 interactions with chain B Hydrogen bonds: B:N.44, B:R.64, B:N.73, B:E.84, B:R.64, B:R.64, B:R.86

Links

RCSB   PDBe   PDBj   PDBsum   CATH   PLIP

Citation

Feng, L. et al., Structural insights into the recognition mechanism between an antitumor galectin AAL and the Thomsen-Friedenreich antigen. Faseb J. (2010)

Release Date

2010-12-01

Peptides

Anti-tumor lectin: AB

SMTL:PDB

SMTL Chain Id:
PDB Chain Id:

A
A

B
B

Anti-tumor lectin

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