SMTL ID : 3ll0.1

Monomeric Griffithsin with two Gly-Ser Insertions

Coordinates

PDB Format

Method

X-RAY DIFFRACTION 1.70 Å

Oligo State

monomer

Ligands

4 x GOL: GLYCEROL(Non-functional Binders)

GOL.1: 7 residues within 4Å: Chain A: G.30, S.31, Y.32, D.34, G.47, G.48, Y.114 5 PLIP interactions: 5 interactions with chain A Hydrogen bonds: A:G.30, A:S.31, A:Y.32, A:Y.32, A:G.48 GOL.2: 7 residues within 4Å: Chain A: Y.32, G.70, D.71, Y.72, D.74, G.93, G.94 8 PLIP interactions: 8 interactions with chain A Hydrogen bonds: A:G.70, A:D.71, A:D.71, A:Y.72, A:Y.72, A:G.94 Water bridges: A:D.71, A:D.74 GOL.3: 7 residues within 4Å: Chain A: G.11, G.12, Y.72, G.112, D.113, Y.114, D.116 7 PLIP interactions: 7 interactions with chain A Hydrogen bonds: A:G.12, A:G.112, A:D.113, A:Y.114, A:Y.114 Water bridges: A:G.12, A:D.113 GOL.4: 6 residues within 4Å: Chain A: S.29, G.30, N.49, P.88, Y.89, G.90 4 PLIP interactions: 4 interactions with chain A Hydrogen bonds: A:G.30, A:N.49, A:P.88, A:G.90

1 x SO4: SULFATE ION(Non-functional Binders)

SO4.5: 1 residues within 4Å: Chain A: S.92 1 PLIP interactions: 1 interactions with chain A Hydrogen bonds: A:S.92

Links

RCSB   PDBe   PDBj   PDBsum   CATH   PLIP

Citation

Moulaei, T. et al., Monomerization of viral entry inhibitor griffithsin elucidates the relationship between multivalent binding to carbohydrates and anti-HIV activity. Structure (2010)

Release Date

2010-10-06

Peptides

Griffithsin: A

SMTL:PDB

SMTL Chain Id:
PDB Chain Id:

A
A

Griffithsin