SMTL ID : 3k43.1

Crystal structure of sCD-MPR mutant E19Q/K137M pH 6.5

Coordinates

PDB Format

Method

X-RAY DIFFRACTION 2.00 Å

Oligo State

homo-dimer

Ligands

2 x NAG: 2-acetamido-2-deoxy-beta-D-glucopyranose(Post Translational Modification)

NAG.1: 2 residues within 4Å: Chain A: N.81, E.82 4 PLIP interactions: 4 interactions with chain A Hydrogen bonds: A:N.81, A:E.82, A:E.82 Water bridges: A:R.79 NAG.5: 4 residues within 4Å: Chain B: S.60, R.79, N.81, E.82 5 PLIP interactions: 5 interactions with chain B Hydrophobic interactions: B:E.82 Hydrogen bonds: B:N.81, B:E.82 Water bridges: B:R.79, B:Q.110

3 x SO4: SULFATE ION(Non-functional Binders)

SO4.2: 3 residues within 4Å: Chain A: R.25, C.153, S.154 3 PLIP interactions: 3 interactions with chain A Water bridges: A:R.25, A:R.25 Salt bridges: A:R.25 SO4.3: 5 residues within 4Å: Chain A: Y.102, D.103, N.104, H.105, R.111 8 PLIP interactions: 8 interactions with chain A Hydrogen bonds: A:D.103, A:D.103, A:N.104, A:N.104 Water bridges: A:R.111, A:R.111 Salt bridges: A:H.105, A:R.111 SO4.7: 5 residues within 4Å: Chain B: Y.102, D.103, N.104, H.105, R.111 7 PLIP interactions: 7 interactions with chain B Hydrogen bonds: B:D.103, B:N.104, B:N.104 Water bridges: B:R.111, B:R.111 Salt bridges: B:H.105, B:R.111

1 x ACT: ACETATE ION(Non-functional Binders)

ACT.4: 3 residues within 4Å: Chain A: N.90, C.119, R.121 2 PLIP interactions: 2 interactions with chain A Hydrogen bonds: A:N.90 Salt bridges: A:R.121

1 x IMD: IMIDAZOLE(Non-covalent)

IMD.6: 3 residues within 4Å: Chain B: R.25, C.153, S.154 3 PLIP interactions: 3 interactions with chain B Hydrogen bonds: B:R.25, B:R.25, B:S.154

Links

RCSB   PDBe   PDBj   PDBsum   CATH   PLIP

Citation

Olson, L.J. et al., Intermonomer interactions are essential for lysosomal enzyme binding by the cation-dependent mannose 6-phosphate receptor. Biochemistry (2010)

Release Date

2009-11-24

Peptides

Cation-dependent mannose-6-phosphate receptor: AB

SMTL:PDB

SMTL Chain Id:
PDB Chain Id:

A
A

B
B

Cation-dependent mannose-6-phosphate receptor

Related Entries With Identical Sequence