SMTL ID : 3ap9.1

Crystal structure of the galectin-8 N-terminal carbohydrate recognition domain in complex with Lacto-N-fucopentaose III

Coordinates

PDB Format

Method

X-RAY DIFFRACTION 1.33 Å

Oligo State

monomer

Ligands

1 x BGC- GAL- NAG- FUC- GAL: alpha-L-fucopyranose-(1-3)-[beta-D-galactopyranose-(1-4)]2-acetamido-2-deoxy-beta-D-glucopyranose-(1-3)-beta-D-galactopyranose-(1-4)-beta-D-glucopyranose

BGC-GAL-NAG-FUC-GAL.1: 14 residues within 4Å: Chain A: R.45, Q.47, D.49, V.56, R.59, H.65, N.67, R.69, N.79, W.86, E.89, Y.141 Ligands: CL.3, CL.5 5 PLIP interactions: 5 interactions with chain A Hydrogen bonds: A:R.69, A:R.69, A:R.59, A:R.59, A:R.45, A:Q.47, A:D.49, A:R.59 Water bridges: A:E.89, A:E.89, A:Y.141, A:D.49

1 x MPD: (4S)-2-METHYL-2,4-PENTANEDIOL(Non-functional Binders)

MPD.2: 1 residues within 4Å: Chain A: I.82 3 PLIP interactions: 3 interactions with chain A Water bridges: A:N.83, A:K.134, A:K.134

3 x CL: CHLORIDE ION(Non-functional Binders)

CL.3: 3 residues within 4Å: Chain A: R.59, W.86 Ligands: BGC-GAL-NAG-FUC-GAL.1 Ligand excluded by PLIP CL.4: 4 residues within 4Å: Chain A: L.110, K.111, D.112, K.113 Ligand excluded by PLIP CL.5: 4 residues within 4Å: Chain A: P.18, Y.141, G.142 Ligands: BGC-GAL-NAG-FUC-GAL.1 Ligand excluded by PLIP

Links

RCSB   PDBe   PDBj   PDBsum   CATH   PLIP

Citation

Ideo, H. et al., Galectin-8-N-domain recognition mechanism for sialylated and sulfated glycans. J.Biol.Chem. (2011)

Release Date

2011-02-02

Peptides

Galectin-8: A

SMTL:PDB

SMTL Chain Id:
PDB Chain Id:

A
A

Galectin-8

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