SMTL ID : 3ap7.1

Crystal structure of the galectin-8 N-terminal carbohydrate recognition domain in complex with lactose sialic acid

Coordinates

PDB Format

Method

X-RAY DIFFRACTION 1.53 Å

Oligo State

monomer

Ligands

1 x BGC- GAL- SIA: N-acetyl-alpha-neuraminic acid-(2-3)-beta-D-galactopyranose-(1-4)-beta-D-glucopyranose(Non-covalent)

BGC-GAL-SIA.1: 9 residues within 4Å: Chain A: R.45, Q.47, R.59, H.65, N.67, R.69, N.79, W.86, E.89 5 PLIP interactions: 5 interactions with chain A Hydrogen bonds: A:R.69, A:R.69, A:E.89, A:R.45, A:R.45, A:R.69, A:N.79, A:E.89, A:Q.47, A:W.86 Water bridges: A:E.89, A:E.89, A:E.89, A:R.45 Salt bridges: A:R.59, A:H.65

1 x CL: CHLORIDE ION(Non-functional Binders)

CL.2: 4 residues within 4Å: Chain A: L.110, K.111, D.112, K.113 Ligand excluded by PLIP

Links

RCSB   PDBe   PDBj   PDBsum   CATH   PLIP

Citation

Ideo, H. et al., Galectin-8-N-domain recognition mechanism for sialylated and sulfated glycans. J.Biol.Chem. (2011)

Release Date

2011-01-26

Peptides

Galectin-8: A

SMTL:PDB

SMTL Chain Id:
PDB Chain Id:

A
A

Galectin-8

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