SMTL ID : 2zgo.1

Crystal structure of AAL mutant H59Q complex with lactose

Coordinates

PDB Format

Method

X-RAY DIFFRACTION 2.00 Å

Oligo State

homo-dimer

Ligands

2 x BGC- GAL: beta-D-galactopyranose-(1-4)-beta-D-glucopyranose(Non-covalent)

BGC-GAL.1: 8 residues within 4Å: Chain A: P.43, N.44, Q.60, R.64, N.73, W.81, E.84, R.86 5 PLIP interactions: 5 interactions with chain A Hydrogen bonds: A:R.64, A:R.64, A:E.84, A:R.86, A:N.44, A:N.44, A:Q.60, A:R.64, A:N.73 Water bridges: A:E.67, A:R.86 BGC-GAL.2: 8 residues within 4Å: Chain B: N.44, Q.60, R.64, I.71, N.73, W.81, E.84, R.86 7 PLIP interactions: 7 interactions with chain B Hydrogen bonds: B:R.64, B:R.64, B:E.84, B:R.86, B:N.44, B:N.44, B:Q.60, B:R.64, B:N.73, B:E.84 Water bridges: B:W.81

Links

RCSB   PDBe   PDBj   PDBsum   CATH   PLIP

Citation

Yang, N. et al., Structural basis for the tumor cell apoptosis-inducing activity of an antitumor lectin from the edible mushroom Agrocybe aegerita. J.Mol.Biol. (2009)

Release Date

2009-01-20

Peptides

Anti-tumor lectin: AB

SMTL:PDB

SMTL Chain Id:
PDB Chain Id:

A
A

B
B

Anti-tumor lectin