SMTL ID : 2z8l.1

Crystal Structure of the Staphylococcal superantigen-like protein SSL5 at pH 4.6 complexed with sialyl Lewis X

Coordinates

PDB Format

Method

X-RAY DIFFRACTION 1.65 Å

Oligo State

monomer

Ligands

1 x NAG- GAL- SIA- FUC: N-acetyl-alpha-neuraminic acid-(2-3)-beta-D-galactopyranose-(1-4)-[alpha-L-fucopyranose-(1-3)]2-acetamido-2-deoxy-beta-D-glucopyranose

NAG-GAL-SIA-FUC.1: 10 residues within 4Å: Chain A: L.141, Y.177, Y.178, T.179, E.181, K.184, Q.187, H.189, R.190, D.193 11 PLIP interactions: 11 interactions with chain A Hydrogen bonds: A:K.184, A:K.184, A:Q.187, A:E.181, A:Q.187, A:Q.187, A:Y.177, A:T.179, A:T.179, A:R.190, A:D.193, A:D.193 Water bridges: A:T.179, A:E.181, A:H.189, A:Y.177, A:Y.177, A:Y.177 Hydrophobic interactions: A:Y.178 Salt bridges: A:R.190

1 x PO4: PHOSPHATE ION(Non-functional Binders)

PO4.2: 4 residues within 4Å: Chain A: K.33, D.78, K.101, N.102 3 PLIP interactions: 3 interactions with chain A Hydrogen bonds: A:N.102 Water bridges: A:N.102, A:N.102

1 x GOL: GLYCEROL(Non-functional Binders)

GOL.3: 9 residues within 4Å: Chain A: H.132, Y.133, I.134, Y.135, K.136, V.139, E.143, L.144, K.147 4 PLIP interactions: 4 interactions with chain A Hydrogen bonds: A:H.132, A:Y.135, A:K.136, A:K.147

Links

RCSB   PDBe   PDBj   PDBsum   CATH   PLIP

Citation

Baker, H.M. et al., Crystal structures of the staphylococcal toxin SSL5 in complex with sialyl Lewis X reveal a conserved binding site that shares common features with viral and bacterial sialic acid binding proteins. J.Mol.Biol. (2007)

Release Date

2007-11-27

Peptides

Exotoxin 3: A

SMTL:PDB

SMTL Chain Id:
PDB Chain Id:

A
A

Exotoxin 3