SMTL ID : 2wbv.1 (1 other biounit)

Canine adenovirus 2 fibre head in complex with sialic acid

Coordinates

PDB Format

Method

X-RAY DIFFRACTION 1.90 Å

Oligo State

homo-trimer

Ligands

1 x GAL- SIA: N-acetyl-alpha-neuraminic acid-(2-3)-beta-D-galactopyranose(Non-functional Binders)

GAL-SIA.1: 10 residues within 4Å: Chain C: I.24, Y.55, Q.62, S.63, Q.64, F.65, S.66, N.82, K.150, R.162 10 PLIP interactions: 10 interactions with chain C Hydrogen bonds: C:K.150, C:K.150, C:S.63, C:Q.64, C:Q.64, C:S.66, C:N.82, C:N.82 Water bridges: C:N.25, C:N.25, C:N.82 Salt bridges: C:R.162

3 x GOL: GLYCEROL(Non-functional Binders)(Non-covalent)

GOL.2: 7 residues within 4Å: Chain A: P.16, G.17, P.18, F.33, S.48 Chain C: E.115, V.116 4 PLIP interactions: 4 interactions with chain A Hydrogen bonds: A:G.17, A:S.48, A:S.48 Water bridges: A:F.33 GOL.3: 8 residues within 4Å: Chain A: E.115, V.116, Y.117 Chain B: P.16, G.17, P.18, F.33, S.48 7 PLIP interactions: 6 interactions with chain B, 1 interactions with chain A Hydrogen bonds: B:G.17 Water bridges: B:F.33, B:S.48, B:S.48, B:S.48, B:S.48, A:S.118 GOL.6: 6 residues within 4Å: Chain B: V.116 Chain C: P.16, G.17, P.18, F.33, S.48 5 PLIP interactions: 4 interactions with chain C, 1 interactions with chain B Hydrogen bonds: C:G.17, C:S.48, B:E.115 Water bridges: C:S.48, C:S.48

2 x SIA: N-acetyl-alpha-neuraminic acid(Non-covalent)(Non-functional Binders)

SIA.4: 9 residues within 4Å: Chain A: I.24, Y.55, Q.62, S.63, Q.64, F.65, S.66, N.82, R.162 10 PLIP interactions: 10 interactions with chain A Hydrophobic interactions: A:F.65 Hydrogen bonds: A:S.63, A:Q.64, A:Q.64, A:S.66, A:N.82, A:N.82 Water bridges: A:Y.55, A:Q.64 Salt bridges: A:R.162 SIA.5: 9 residues within 4Å: Chain B: I.24, Y.55, Q.62, S.63, Q.64, F.65, S.66, N.82, R.162 11 PLIP interactions: 11 interactions with chain B Hydrophobic interactions: B:F.65 Hydrogen bonds: B:Q.64, B:Q.64, B:S.66, B:N.82, B:N.82 Water bridges: B:N.25, B:S.63, B:Q.64, B:N.82 Salt bridges: B:R.162

Links

RCSB   PDBe   PDBj   PDBsum   CATH   PLIP

Citation

Seiradake, E. et al., The Cell Adhesion Molecule "Car" and Sialic Acid on Human Erythrocytes Influence Adenovirus in Vivo Biodistribution. Plos Pathog. (2009)

Release Date

2009-03-17

Peptides

FIBER PROTEIN: ABC

SMTL:PDB

SMTL Chain Id:
PDB Chain Id:

A
A

B
B

C
D

FIBER PROTEIN

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