SMTL ID : 2rl7.1 (1 other biounit)

Crystal Structure cation-dependent mannose 6-phosphate receptor at pH 4.8

Coordinates

PDB Format

Method

X-RAY DIFFRACTION 2.00 Å

Oligo State

homo-dimer

Ligands

2 x NAG- NAG: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose(Non-covalent)(Non-functional Binders)

NAG-NAG.1: 3 residues within 4Å: Chain A: R.79, N.81, E.82 2 PLIP interactions: 2 interactions with chain A Water bridges: A:Q.110, A:Q.110 NAG-NAG.2: 3 residues within 4Å: Chain B: R.79, N.81, E.82 No protein-ligand interaction detected (PLIP)

1 x GOL: GLYCEROL(Non-functional Binders)

GOL.3: 6 residues within 4Å: Chain A: H.58, S.59, E.74, T.75, V.76, D.100 4 PLIP interactions: 4 interactions with chain A Hydrogen bonds: A:E.74, A:V.76, A:D.100 Water bridges: A:H.58

2 x ACT: ACETATE ION(Non-covalent)(Non-functional Binders)

ACT.4: 4 residues within 4Å: Chain B: P.130, V.131, E.133, R.135 2 PLIP interactions: 2 interactions with chain B Hydrogen bonds: B:P.130, B:R.135 ACT.5: 3 residues within 4Å: Chain B: H.122, T.123, D.126 6 PLIP interactions: 6 interactions with chain B Hydrophobic interactions: B:D.126 Hydrogen bonds: B:T.123, B:D.126, B:D.126 Water bridges: B:N.127 Salt bridges: B:H.122

1 x CAC: CACODYLATE ION(Non-functional Binders)

CAC.6: 7 residues within 4Å: Chain B: F.34, E.35, S.36, D.126, N.127, F.128, N.129 No protein-ligand interaction detected (PLIP)

Links

RCSB   PDBe   PDBj   PDBsum   CATH   PLIP

Citation

Olson, L.J. et al., Structural Insights into the Mechanism of pH-dependent Ligand Binding and Release by the Cation-dependent Mannose 6-Phosphate Receptor. J.Biol.Chem. (2008)

Release Date

2008-02-12

Peptides

Cation-dependent mannose-6-phosphate receptor: AB

SMTL:PDB

SMTL Chain Id:
PDB Chain Id:

A
A

B
B

Cation-dependent mannose-6-phosphate receptor

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