SMTL ID : 2n7b.1

Solution structure of the human Siglec-8 lectin domain in complex with 6'sulfo sialyl Lewisx

Coordinates

PDB Format

Method

SOLUTION NMR

Oligo State

monomer

Ligands

1 x NAG- G6S- SIA- FUC: N-acetyl-alpha-neuraminic acid-(2-3)-6-O-sulfo-beta-D-galactopyranose-(1-4)-[alpha-L-fucopyranose-(1-3)]2-acetamido-2-deoxy-beta-D-glucopyranose(Non-functional Binders)

NAG-G6S-SIA-FUC.1: 13 residues within 4Å: Chain A: Y.7, Y.11, R.56, Y.58, Q.59, R.109, K.116, W.117, S.118, K.120, Q.122, L.123 Ligands: 0D8.2 11 PLIP interactions: 11 interactions with chain A Hydrogen bonds: A:Q.59, A:Y.58, A:Y.58, A:K.120, A:Y.7, A:Y.58, A:R.109, A:K.116, A:S.118, A:S.118, A:K.120, A:Q.122 Salt bridges: A:R.56, A:R.109, A:K.116 Hydrophobic interactions: A:W.117

1 x 0D8: 3-aminopropan-1-ol

0D8.2: 4 residues within 4Å: Chain A: S.121, Q.122, L.123 Ligands: NAG-G6S-SIA-FUC.1 No protein-ligand interaction detected (PLIP)

Links

RCSB   PDBe   PDBj   PDBsum   CATH   PLIP

Citation

Propster, J.M. et al., Structural basis for sulfation-dependent self-glycan recognition by the human immune-inhibitory receptor Siglec-8. Proc.Natl.Acad.Sci.USA (2016)

Release Date

2016-07-06

Peptides

Sialic acid-binding Ig-like lectin 8: A

SMTL:PDB

SMTL Chain Id:
PDB Chain Id:

A
A

Sialic acid-binding Ig-like lectin 8

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