SMTL ID : 2jhm.1

Structure of globular heads of M-ficolin at neutral pH

Coordinates

PDB Format

Method

X-RAY DIFFRACTION 1.52 Å

Oligo State

monomer

Ligands

1 x CA: CALCIUM ION(Non-covalent)

CA.1: 4 residues within 4Å: Chain A: D.154, D.156, S.158, S.160 5 PLIP interactions: 5 interactions with chain A Metal complexes: A:D.154, A:D.154, A:D.156, A:S.158, A:S.160

1 x EPE: 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID(Non-functional Binders)

EPE.2: 6 residues within 4Å: Chain A: S.21, L.37, D.39, R.52, E.212, K.214 5 PLIP interactions: 5 interactions with chain A Hydrogen bonds: A:D.39 Water bridges: A:S.21, A:S.21 Salt bridges: A:R.52, A:K.214

1 x IPA: ISOPROPYL ALCOHOL(Non-functional Binders)

IPA.3: 5 residues within 4Å: Chain A: F.166, D.174, C.175, H.176, A.193 1 PLIP interactions: 1 interactions with chain A Hydrogen bonds: A:H.176

Links

RCSB   PDBe   PDBj   PDBsum   CATH   PLIP

Citation

Garlatti, V. et al., Structural Basis for Innate Immune Sensing by M-Ficolin and its Control by a Ph-Dependent Conformational Switch. J.Biol.Chem. (2007)

Release Date

2007-10-09

Peptides

FICOLIN-1: A

SMTL:PDB

SMTL Chain Id:
PDB Chain Id:

A
F

FICOLIN-1

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