SMTL ID : 2j3o.1 (1 other biounit)

L-ficolin complexed to N-acetyl-D-glucosamine

Coordinates

PDB Format

Method

X-RAY DIFFRACTION 2.65 Å

Oligo State

homo-trimer

Ligands

3 x CA: CALCIUM ION(Non-covalent)

CA.1: 6 residues within 4Å: Chain A: D.155, D.157, N.159, T.160, G.161, N.162 2 PLIP interactions: 2 interactions with chain A Metal complexes: A:D.155, A:G.161 CA.4: 4 residues within 4Å: Chain B: D.155, D.157, N.159, G.161 5 PLIP interactions: 5 interactions with chain B Metal complexes: B:D.155, B:D.155, B:D.157, B:N.159, B:G.161 CA.9: 4 residues within 4Å: Chain C: D.155, D.157, N.159, G.161 5 PLIP interactions: 5 interactions with chain C Metal complexes: C:D.155, C:D.155, C:D.157, C:N.159, C:G.161

2 x ACT: ACETATE ION(Non-functional Binders)

ACT.2: 5 residues within 4Å: Chain A: T.36, R.75 Chain B: H.19, L.21, H.25 4 PLIP interactions: 3 interactions with chain B, 1 interactions with chain A Hydrophobic interactions: B:H.19, B:L.21 Hydrogen bonds: B:G.18 Salt bridges: A:R.75 ACT.5: 6 residues within 4Å: Chain B: F.167, N.175, C.176, H.177, F.193, Y.205 5 PLIP interactions: 5 interactions with chain B Hydrophobic interactions: B:F.193 Hydrogen bonds: B:N.175, B:C.176, B:H.177 Salt bridges: B:H.177

4 x NAG: 2-acetamido-2-deoxy-beta-D-glucopyranose(Non-covalent)

NAG.3: 9 residues within 4Å: Chain A: S.74 Chain B: S.22, D.40, T.43, R.53, D.100, Y.108, E.213, K.215 6 PLIP interactions: 6 interactions with chain B Hydrogen bonds: B:D.40, B:T.43, B:R.53, B:D.100, B:K.215 Water bridges: B:S.22 NAG.6: 1 residues within 4Å: Chain B: N.146 2 PLIP interactions: 2 interactions with chain B Hydrogen bonds: B:N.146, B:N.146 NAG.7: 9 residues within 4Å: Chain A: S.22, D.40, V.50, R.53, E.213 Chain C: S.58, V.59, S.74, L.76 7 PLIP interactions: 3 interactions with chain C, 4 interactions with chain A Hydrogen bonds: C:S.74, C:S.74, C:L.76, A:S.22, A:S.22, A:R.53 Salt bridges: A:R.53 NAG.8: 11 residues within 4Å: Chain B: S.74, L.76 Chain C: L.38, D.40, T.43, R.53, D.100, Y.108, V.211, E.213, K.215 8 PLIP interactions: 7 interactions with chain C, 1 interactions with chain B Hydrophobic interactions: C:L.38, C:D.40 Hydrogen bonds: C:R.53, C:D.100, C:D.100, C:E.213, B:S.74 Salt bridges: C:K.215

Links

RCSB   PDBe   PDBj   PDBsum   CATH   PLIP

Citation

Garlatti, V. et al., Structural Insights Into the Innate Immune Recognition Specificities of L- and H-Ficolins. Embo J. (2007)

Release Date

2007-01-23

Peptides

FICOLIN-2: ABC

SMTL:PDB

SMTL Chain Id:
PDB Chain Id:

A
A

B
B

C
C

FICOLIN-2

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