SMTL ID : 2j3f.1 (1 other biounit)

L-ficolin complexed to N-acetyl-D-galactosamine

Coordinates

PDB Format

Method

X-RAY DIFFRACTION 2.80 Å

Oligo State

homo-trimer

Ligands

1 x NAG- NAG- BMA- MAN- FUC: alpha-D-mannopyranose-(1-6)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose(Non-covalent)

NAG-NAG-BMA-MAN-FUC.1: 5 residues within 4Å: Chain B: N.126, N.146, Q.147, S.148, L.158 4 PLIP interactions: 4 interactions with chain B Hydrogen bonds: B:Q.147, B:Q.147, B:S.148, B:S.148

3 x CA: CALCIUM ION(Non-covalent)(Post Translational Modification)(Non-functional Binders)

CA.2: 5 residues within 4Å: Chain A: D.155, D.157, N.159, T.160, G.161 3 PLIP interactions: 3 interactions with chain A Metal complexes: A:D.155, A:D.157, A:N.159 CA.4: 4 residues within 4Å: Chain B: D.155, D.157, N.159, G.161 5 PLIP interactions: 4 interactions with chain B, 1 Ligand-Water interactions Metal complexes: B:D.155, B:D.157, B:N.159, B:G.161, H2O.1 CA.7: 4 residues within 4Å: Chain C: D.155, D.157, N.159, G.161 5 PLIP interactions: 5 interactions with chain C Metal complexes: C:D.155, C:D.155, C:D.157, C:N.159, C:G.161

2 x A2G: 2-acetamido-2-deoxy-alpha-D-galactopyranose(Non-covalent)

A2G.3: 3 residues within 4Å: Chain B: R.63, D.64, T.67 1 PLIP interactions: 1 interactions with chain B Hydrogen bonds: B:D.64 A2G.6: 2 residues within 4Å: Chain C: R.63, D.64 3 PLIP interactions: 3 interactions with chain C Hydrogen bonds: C:R.63, C:D.64, C:D.64

1 x P4C: O-ACETALDEHYDYL-HEXAETHYLENE GLYCOL(Non-functional Binders)

P4C.5: 10 residues within 4Å: Chain A: D.56, S.58, L.76, R.187 Chain B: V.55, V.102, D.103, F.104, D.106, K.210 2 PLIP interactions: 2 interactions with chain B Hydrogen bonds: B:K.210 Salt bridges: B:K.210

Links

RCSB   PDBe   PDBj   PDBsum   CATH   PLIP

Citation

Garlatti, V. et al., Structural Insights Into the Innate Immune Recognition Specificities of L- and H-Ficolins. Embo J. (2007)

Release Date

2007-01-23

Peptides

FICOLIN-2: ABC

SMTL:PDB

SMTL Chain Id:
PDB Chain Id:

A
A

B
B

C
C

FICOLIN-2

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