SMTL ID : 2j2p.1 (1 other biounit)

L-ficolin complexed to N-acetyl-cystein (150mM)

Coordinates

PDB Format

Method

X-RAY DIFFRACTION 2.80 Å

Oligo State

homo-trimer

Ligands

1 x NAG- NAG: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose(Non-covalent)

NAG-NAG.1: 1 residues within 4Å: Chain B: N.145 No protein-ligand interaction detected (PLIP)

3 x CA: CALCIUM ION(Non-covalent)(Post Translational Modification)

CA.2: 4 residues within 4Å: Chain A: D.154, D.156, N.158, G.160 5 PLIP interactions: 5 interactions with chain A Metal complexes: A:D.154, A:D.154, A:D.156, A:N.158, A:G.160 CA.6: 4 residues within 4Å: Chain B: D.154, D.156, N.158, G.160 5 PLIP interactions: 5 interactions with chain B Metal complexes: B:D.154, B:D.154, B:D.156, B:N.158, B:G.160 CA.11: 4 residues within 4Å: Chain C: D.154, D.156, N.158, G.160 5 PLIP interactions: 5 interactions with chain C Metal complexes: C:D.154, C:D.154, C:D.156, C:N.158, C:G.160

6 x SC2: N-ACETYL-L-CYSTEINE(Non-covalent)(Non-functional Binders)

SC2.3: 8 residues within 4Å: Chain A: D.55, S.57, L.75, G.76 Chain B: R.52, L.75 Ligands: SC2.5, SC2.8 3 PLIP interactions: 1 interactions with chain A, 2 interactions with chain B Hydrogen bonds: A:L.75, B:R.52 Salt bridges: B:R.52 SC2.4: 5 residues within 4Å: Chain B: Y.61, R.62, D.63, T.66, K.151 4 PLIP interactions: 4 interactions with chain B Hydrogen bonds: B:R.62, B:D.63, B:T.66 Salt bridges: B:R.62 SC2.5: 9 residues within 4Å: Chain A: S.73, L.75 Chain B: S.21, L.37, D.39, D.41, R.52, E.212 Ligands: SC2.3 6 PLIP interactions: 5 interactions with chain B, 1 interactions with chain A Hydrogen bonds: B:R.52, B:E.212, B:E.212, A:S.73 Salt bridges: B:R.52, B:K.214 SC2.7: 9 residues within 4Å: Chain B: V.58, G.72, S.73, L.75 Chain C: S.21, L.37, D.39, D.41, E.212 4 PLIP interactions: 1 interactions with chain B, 3 interactions with chain C Hydrophobic interactions: B:L.75 Hydrogen bonds: C:S.21, C:S.21, C:D.39 SC2.8: 8 residues within 4Å: Chain A: R.52 Chain C: D.55, S.57, S.73, L.75, G.76, E.77 Ligands: SC2.3 4 PLIP interactions: 2 interactions with chain A, 2 interactions with chain C Hydrogen bonds: A:R.52, C:S.73 Salt bridges: A:R.52 Hydrophobic interactions: C:L.75 SC2.9: 4 residues within 4Å: Chain C: R.62, D.63, T.66, K.151 4 PLIP interactions: 4 interactions with chain C Hydrophobic interactions: C:R.62, C:T.66 Hydrogen bonds: C:D.63, C:K.151

1 x BMA: beta-D-mannopyranose(Non-covalent)

BMA.10: 6 residues within 4Å: Chain C: F.166, N.174, C.175, H.176, F.192, Y.204 2 PLIP interactions: 2 interactions with chain C Hydrogen bonds: C:C.175, C:H.176

Links

RCSB   PDBe   PDBj   PDBsum   CATH   PLIP

Citation

Garlatti, V. et al., Structural Insights Into the Innate Immune Recognition Specificities of L- and H-Ficolins. Embo J. (2007)

Release Date

2007-01-23

Peptides

FICOLIN-2: ABC

SMTL:PDB

SMTL Chain Id:
PDB Chain Id:

A
A

B
B

C
C

FICOLIN-2

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