SMTL ID : 2j1g.1 (1 other biounit)

L-ficolin complexed to N-acetyl-cystein

Coordinates

PDB Format

Method

X-RAY DIFFRACTION 1.95 Å

Oligo State

homo-trimer

Ligands

1 x NAG- NAG- BMA- MAN- FUC: alpha-D-mannopyranose-(1-6)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose(Non-functional Binders)

NAG-NAG-BMA-MAN-FUC.1: 5 residues within 4Å: Chain B: N.125, N.145, Q.146, S.147, L.157 5 PLIP interactions: 5 interactions with chain B Hydrogen bonds: B:N.125, B:Q.146, B:S.147, B:S.147 Water bridges: B:S.147

3 x ACT: ACETATE ION(Non-covalent)(Non-functional Binders)

ACT.2: 7 residues within 4Å: Chain B: F.166, N.174, C.175, H.176, F.192, A.193, Y.204 8 PLIP interactions: 8 interactions with chain B Hydrophobic interactions: B:F.166, B:F.192, B:A.193, B:Y.204 Hydrogen bonds: B:C.175, B:H.176 Water bridges: B:Y.204 Salt bridges: B:H.176 ACT.6: 7 residues within 4Å: Chain C: F.166, N.174, C.175, H.176, F.192, A.193, Y.204 7 PLIP interactions: 7 interactions with chain C Hydrophobic interactions: C:F.166, C:F.192, C:A.193, C:Y.204 Hydrogen bonds: C:C.175, C:H.176 Water bridges: C:Y.204 ACT.7: 6 residues within 4Å: Chain C: S.21, L.37, D.39, R.52, E.212, K.214 3 PLIP interactions: 3 interactions with chain C Hydrogen bonds: C:D.39 Salt bridges: C:R.52, C:K.214

2 x CA: CALCIUM ION(Post Translational Modification)(Covalent)

CA.3: 4 residues within 4Å: Chain B: D.154, D.156, N.158, G.160 5 PLIP interactions: 3 interactions with chain B, 2 Ligand-Water interactions Metal complexes: B:D.154, B:D.154, B:G.160, H2O.9, H2O.9 CA.8: 4 residues within 4Å: Chain C: D.154, D.156, N.158, G.160 5 PLIP interactions: 3 interactions with chain C, 2 Ligand-Water interactions Metal complexes: C:D.154, C:D.154, C:G.160, H2O.16, H2O.16

2 x P4C: O-ACETALDEHYDYL-HEXAETHYLENE GLYCOL(Non-functional Binders)(Non-covalent)

P4C.4: 10 residues within 4Å: Chain A: D.55, S.57, R.186 Chain B: V.54, V.101, D.102, F.103, D.105, K.209 Ligands: P4C.5 6 PLIP interactions: 3 interactions with chain B, 3 interactions with chain A Hydrogen bonds: B:D.105, B:K.209 Water bridges: B:R.52, A:S.57, A:R.186, A:R.186 P4C.5: 2 residues within 4Å: Chain B: R.186 Ligands: P4C.4 1 PLIP interactions: 1 interactions with chain B Hydrogen bonds: B:R.186

Links

RCSB   PDBe   PDBj   PDBsum   CATH   PLIP

Citation

Garlatti, V. et al., Structural Insights Into the Innate Immune Recognition Specificities of L- and H-Ficolins. Embo J. (2007)

Release Date

2007-01-23

Peptides

FICOLIN-2: ABC

SMTL:PDB

SMTL Chain Id:
PDB Chain Id:

A
A

B
B

C
C

FICOLIN-2

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