SMTL ID : 2df3.1

The structure of Siglec-7 in complex with alpha(2,3)/alpha(2,6) disialyl lactotetraosyl 2-(trimethylsilyl)ethyl

Coordinates

PDB Format

Method

X-RAY DIFFRACTION 1.90 Å

Oligo State

monomer

Ligands

1 x NAG- GAL- SIA- SIA: N-acetyl-alpha-neuraminic acid-(2-3)-beta-D-galactopyranose-(1-3)-[N-acetyl-alpha-neuraminic acid-(2-6)]2-acetamido-2-deoxy-beta-D-glucopyranose(Post Translational Modification)

NAG-GAL-SIA-SIA.1: 5 residues within 4Å: Chain A: Y.9, R.107, K.114, W.115, N.116 7 PLIP interactions: 7 interactions with chain A Water bridges: A:N.116, A:K.114, A:K.114, A:N.116 Hydrogen bonds: A:K.114, A:N.116, A:N.116 Salt bridges: A:R.107

1 x NAG: 2-acetamido-2-deoxy-beta-D-glucopyranose(Non-covalent)

NAG.2: 4 residues within 4Å: Chain A: R.28, L.81, N.88, T.90 3 PLIP interactions: 3 interactions with chain A Hydrogen bonds: A:N.88 Water bridges: A:R.28, A:D.83

1 x CYS: CYSTEINE(Non-functional Binders)

CYS.3: 3 residues within 4Å: Chain A: C.24, V.25, H.26 3 PLIP interactions: 1 interactions with chain A, 2 Ligand-Ligand interactions Salt bridges: A:H.26 Hydrogen bonds: C.3, C.3

Links

RCSB   PDBe   PDBj   PDBsum   CATH   PLIP

Citation

Attrill, H. et al., The structure of siglec-7 in complex with sialosides: leads for rational structure-based inhibitor design. Biochem.J. (2006)

Release Date

2006-06-20

Peptides

Sialic acid-binding Ig-like lectin 7: A

SMTL:PDB

SMTL Chain Id:
PDB Chain Id:

A
A

Sialic acid-binding Ig-like lectin 7

Related Entries With Identical Sequence