SMTL ID : 2d6o.1

Crystal structure of mouse galectin-9 N-terminal CRD in complex with N-acetyllactosamine dimer

Coordinates

PDB Format

Method

X-RAY DIFFRACTION 1.78 Å

Oligo State

homo-dimer

Ligands

2 x NAG- GAL- NAG- GAL: beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-3)-beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose(Non-covalent)(Non-functional Binders)

NAG-GAL-NAG-GAL.1: 11 residues within 4Å: Chain A: H.62, N.64, R.66, V.74, N.76, W.83, E.86, R.88 Chain B: E.69, G.70, M.90 6 PLIP interactions: 6 interactions with chain A Hydrogen bonds: A:N.64, A:R.66, A:N.76, A:R.66, A:R.66, A:R.88 Water bridges: A:N.64, A:R.66, A:R.45, A:R.88, A:R.88 NAG-GAL-NAG-GAL.3: 11 residues within 4Å: Chain A: E.69, G.70, M.90 Chain B: H.62, N.64, R.66, V.74, N.76, W.83, E.86, R.88 6 PLIP interactions: 6 interactions with chain B Hydrogen bonds: B:N.64, B:R.66, B:N.76, B:E.86, B:R.66, B:R.66, B:R.88 Water bridges: B:R.45, B:N.64, B:R.45, B:R.88, B:R.88

2 x GOL: GLYCEROL(Non-covalent)

GOL.2: 1 residues within 4Å: Chain A: G.139 No protein-ligand interaction detected (PLIP) GOL.4: 1 residues within 4Å: Chain B: G.139 No protein-ligand interaction detected (PLIP)

Links

RCSB   PDBe   PDBj   PDBsum   CATH   PLIP

Citation

Nagae, M. et al., Crystal Structure of the Galectin-9 N-terminal Carbohydrate Recognition Domain from Mus musculus Reveals the Basic Mechanism of Carbohydrate Recognition. J.Biol.Chem. (2006)

Release Date

2006-09-26

Peptides

lectin, galactose binding, soluble 9: AB

SMTL:PDB

SMTL Chain Id:
PDB Chain Id:

A
X

B
X

lectin, galactose binding, soluble 9