SMTL ID : 2cl8.1

Dectin-1 in complex with beta-glucan

Coordinates

PDB Format

Method

X-RAY DIFFRACTION 2.80 Å

Oligo State

homo-dimer

Ligands

1 x BGC- BGC- BGC: beta-D-glucopyranose-(1-3)-beta-D-glucopyranose-(1-3)-beta-D-glucopyranose(Non-covalent)

BGC-BGC-BGC.1: 12 residues within 4Å: Chain A: R.33, S.36, G.39, A.40, H.41, E.82, E.131 Chain B: S.36, G.39, H.41, E.82, E.131 2 PLIP interactions: 2 interactions with chain A Hydrogen bonds: A:E.82, A:E.131

2 x CA: CALCIUM ION(Non-functional Binders)(Non-covalent)

CA.2: 4 residues within 4Å: Chain A: K.44, D.46, E.50, E.129 5 PLIP interactions: 3 interactions with chain A, 2 Ligand-Water interactions Metal complexes: A:K.44, A:D.46, A:E.129, H2O.1, H2O.1 CA.4: 4 residues within 4Å: Chain B: K.44, D.46, E.50, E.129 5 PLIP interactions: 4 interactions with chain B, 1 Ligand-Water interactions Metal complexes: B:K.44, B:D.46, B:E.50, B:E.129, H2O.1

4 x CL: CHLORIDE ION(Non-covalent)(Non-functional Binders)

CL.3: 4 residues within 4Å: Chain A: K.32, H.41, L.42, E.82 Ligand excluded by PLIP CL.5: 3 residues within 4Å: Chain B: F.92, Q.93, R.95 Ligand excluded by PLIP CL.6: 4 residues within 4Å: Chain B: K.32, H.41, L.42, E.82 Ligand excluded by PLIP CL.7: 3 residues within 4Å: Chain B: R.95, S.113, E.114 Ligand excluded by PLIP

Links

RCSB   PDBe   PDBj   PDBsum   CATH   PLIP

Citation

Brown, J. et al., Structure of the Fungal Beta-Glucan-Binding Immune Receptor Dectin-1: Implications for Function. Protein Sci. (2007)

Release Date

2007-05-15

Peptides

DECTIN-1: AB

SMTL:PDB

SMTL Chain Id:
PDB Chain Id:

A
A

B
B

DECTIN-1