SMTL ID : 1y2v.1

Crystal structure of the common edible mushroom (Agaricus bisporus) lectin in complex with T-antigen

Coordinates

PDB Format

Method

X-RAY DIFFRACTION 1.90 Å

Oligo State

homo-tetramer

Ligands

4 x NGA- GAL: beta-D-galactopyranose-(1-3)-2-acetamido-2-deoxy-beta-D-galactopyranose(Non-covalent)

NGA-GAL.1: 10 residues within 4Å: Chain A: Y.27, A.28, S.47, G.48, H.71, N.72, Y.73, Y.97, R.106 Ligands: SER.3 4 PLIP interactions: 4 interactions with chain A Hydrogen bonds: A:A.28, A:S.47, A:G.48, A:N.72, A:R.106 Water bridges: A:K.26, A:G.30 Hydrophobic interactions: A:Y.73 NGA-GAL.2: 10 residues within 4Å: Chain B: Y.27, A.28, S.47, G.48, H.71, N.72, Y.73, Y.97, R.106 Ligands: SER.4 6 PLIP interactions: 6 interactions with chain B Hydrogen bonds: B:A.28, B:S.47, B:G.48, B:H.71, B:N.72 Water bridges: B:K.26, B:N.29, B:S.47, B:R.106, B:R.106 Hydrophobic interactions: B:Y.73 NGA-GAL.5: 10 residues within 4Å: Chain C: Y.27, A.28, S.47, G.48, H.71, N.72, Y.73, Y.97, R.106 Ligands: SER.7 5 PLIP interactions: 5 interactions with chain C Hydrogen bonds: C:A.28, C:S.47, C:G.48, C:H.71, C:N.72, C:R.106 Water bridges: C:K.26, C:G.30 Hydrophobic interactions: C:Y.73 NGA-GAL.6: 10 residues within 4Å: Chain D: Y.27, A.28, S.47, G.48, H.71, N.72, Y.73, Y.97, R.106 Ligands: SER.8 5 PLIP interactions: 5 interactions with chain D Hydrogen bonds: D:A.28, D:S.47, D:G.48, D:N.72 Water bridges: D:K.26, D:N.29, D:S.47, D:R.106, D:R.106 Hydrophobic interactions: D:Y.73

4 x SER: SERINE(Non-covalent)

SER.3: 2 residues within 4Å: Chain A: N.72 Ligands: NGA-GAL.1 1 PLIP interactions: 1 interactions with chain A Hydrogen bonds: A:N.72 SER.4: 2 residues within 4Å: Chain B: N.72 Ligands: NGA-GAL.2 1 PLIP interactions: 1 interactions with chain B Hydrogen bonds: B:N.72 SER.7: 2 residues within 4Å: Chain C: N.72 Ligands: NGA-GAL.5 1 PLIP interactions: 1 interactions with chain C Hydrogen bonds: C:N.72 SER.8: 2 residues within 4Å: Chain D: N.72 Ligands: NGA-GAL.6 1 PLIP interactions: 1 interactions with chain D Hydrogen bonds: D:N.72

Links

RCSB   PDBe   PDBj   PDBsum   CATH   PLIP

Citation

Carrizo, M.E. et al., The Antineoplastic Lectin of the Common Edible Mushroom (Agaricus bisporus) Has Two Binding Sites, Each Specific for a Different Configuration at a Single Epimeric Hydroxyl. J.Biol.Chem. (2005)

Release Date

2004-12-21

Peptides

lectin: ABCD

SMTL:PDB

SMTL Chain Id:
PDB Chain Id:

A
A

B
B

C
A

D
B

lectin

Related Entries With Identical Sequence