SMTL ID : 1w6q.1

X-RAY CRYSTAL STRUCTURE OF R111H HUMAN GALECTIN-1

Coordinates

PDB Format

Method

X-RAY DIFFRACTION 2.10 Å

Oligo State

homo-dimer

Ligands

6 x BME: BETA-MERCAPTOETHANOL(Non-functional Binders)

BME.1: 5 residues within 4Å: Chain A: C.60, Q.72, R.73, E.74, F.106 3 PLIP interactions: 3 interactions with chain A Hydrogen bonds: A:Q.72, A:R.73, A:E.74 BME.2: 6 residues within 4Å: Chain A: E.86, V.87, C.88, K.99, L.100, P.101 No protein-ligand interaction detected (PLIP) BME.3: 7 residues within 4Å: Chain A: R.18, V.19, R.20, C.130, V.131, A.132 Chain B: C.130 3 PLIP interactions: 3 interactions with chain A Hydrogen bonds: A:V.19 Water bridges: A:V.19, A:R.20 BME.4: 3 residues within 4Å: Chain B: C.16, C.88, I.89 No protein-ligand interaction detected (PLIP) BME.5: 5 residues within 4Å: Chain B: R.18, E.86, C.88, K.99, P.101 1 PLIP interactions: 1 interactions with chain B Water bridges: B:G.103 BME.6: 6 residues within 4Å: Chain B: R.18, R.20, E.86, C.130, V.131, A.132 1 PLIP interactions: 1 interactions with chain B Hydrogen bonds: B:E.86

Links

RCSB   PDBe   PDBj   PDBsum   CATH   PLIP

Citation

Lopez-Lucendo, M.I.F. et al., Growth-Regulatory Human Galectin-1: Crystallographic Characterisation of the Structural Changes Induced by Single-Site Mutations and Their Impact on the Thermodynamics of Ligand Binding. J.Mol.Biol. (2004)

Release Date

2004-10-20

Peptides

GALECTIN-1: AB

SMTL:PDB

SMTL Chain Id:
PDB Chain Id:

A
A

B
B

GALECTIN-1