SMTL ID : 1sz0.1

N-terminal 3 domains of CI-MPR bound to mannose 6-phosphate

Coordinates

PDB Format

Method

X-RAY DIFFRACTION 2.10 Å

Oligo State

homo-dimer

Ligands

1 x NDG- NAG: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-alpha-D-glucopyranose(Post Translational Modification)

NDG-NAG.1: 2 residues within 4Å: Chain A: N.76, Q.89 3 PLIP interactions: 3 interactions with chain A Water bridges: A:L.65, A:T.67, A:T.67

2 x NAG- NAG: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose(Post Translational Modification)

NAG-NAG.2: 5 residues within 4Å: Chain B: L.65, T.67, E.74, N.76, Q.89 4 PLIP interactions: 4 interactions with chain B Hydrogen bonds: B:T.67, B:T.67, B:E.74, B:Q.89 NAG-NAG.3: 4 residues within 4Å: Chain B: E.116, R.288, Q.364, N.365 No protein-ligand interaction detected (PLIP)

1 x NAG: 2-acetamido-2-deoxy-beta-D-glucopyranose(Post Translational Modification)

NAG.4: 2 residues within 4Å: Chain A: Q.364, N.365 3 PLIP interactions: 3 interactions with chain A Hydrogen bonds: A:N.365 Water bridges: A:E.116, A:R.118

2 x OS: OSMIUM ION(Non-covalent)

OS.5: 2 residues within 4Å: Chain A: R.200, K.265 3 PLIP interactions: 3 interactions with chain A Hydrogen bonds: A:R.200, A:R.200, A:K.265 OS.7: 2 residues within 4Å: Chain B: R.200, F.236 1 PLIP interactions: 1 interactions with chain B Hydrogen bonds: B:R.200

2 x M6P: 6-O-phosphono-alpha-D-mannopyranose(Non-covalent)

M6P.6: 9 residues within 4Å: Chain A: Y.324, Q.348, Q.356, C.385, S.386, R.391, E.416, C.419, Y.421 11 PLIP interactions: 10 interactions with chain A, 1 interactions with chain B Hydrogen bonds: A:Y.324, A:Y.324, A:Q.348, A:Q.348, A:Q.356, A:S.386, A:R.391, A:E.416 Water bridges: A:S.387 Salt bridges: A:R.391, B:K.350 M6P.8: 9 residues within 4Å: Chain A: K.350 Chain B: Y.324, Q.348, C.385, S.386, R.391, E.416, C.419, Y.421 15 PLIP interactions: 13 interactions with chain B, 2 interactions with chain A Hydrogen bonds: B:Y.324, B:Y.324, B:Q.348, B:Q.348, B:S.386, B:S.386, B:R.391, B:E.416 Water bridges: B:K.358, B:S.387, B:E.416, A:D.353 Salt bridges: B:K.358, B:R.391, A:K.350

Links

RCSB   PDBe   PDBj   PDBsum   CATH   PLIP

Citation

Olson, L.J. et al., The N-terminal carbohydrate recognition site of the cation-independent mannose 6-phosphate receptor. J.Biol.Chem. (2004)

Release Date

2004-06-29

Peptides

cation-independent mannose 6-phosphate receptor: AB

SMTL:PDB

SMTL Chain Id:
PDB Chain Id:

A
A

B
B

cation-independent mannose 6-phosphate receptor

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