SMTL ID : 1sl6.1 (5 other biounits)

Crystal Structure of a fragment of DC-SIGNR (containg the carbohydrate recognition domain and two repeats of the neck) complexed with Lewis-x.

Coordinates

PDB Format

Method

X-RAY DIFFRACTION 2.25 Å

Oligo State

monomer

Ligands

1 x NDG- FUC- GAL: alpha-L-fucopyranose-(1-3)-[beta-D-galactopyranose-(1-4)]2-acetamido-2-deoxy-alpha-D-glucopyranose

NDG-FUC-GAL.1: 8 residues within 4Å: Chain A: E.144, N.146, S.148, E.151, N.162, D.163, N.164 Ligands: CA.3 4 PLIP interactions: 4 interactions with chain A Hydrogen bonds: A:N.146, A:E.151, A:N.162, A:N.162, A:N.164 Water bridges: A:N.162, A:N.162, A:N.162

4 x CA: CALCIUM ION(Non-covalent)

CA.2: 6 residues within 4Å: Chain A: D.117, E.121, N.147, E.151, D.152 Ligands: CA.4 5 PLIP interactions: 4 interactions with chain A, 1 Ligand-Water interactions Metal complexes: A:D.117, A:D.117, A:E.121, A:D.152, H2O.1 CA.3: 6 residues within 4Å: Chain A: E.144, N.146, E.151, N.162, D.163 Ligands: NDG-FUC-GAL.1 4 PLIP interactions: 4 interactions with chain A Metal complexes: A:E.144, A:E.151, A:D.163, A:D.163 CA.4: 4 residues within 4Å: Chain A: E.121, N.150, D.152 Ligands: CA.2 5 PLIP interactions: 3 interactions with chain A, 2 Ligand-Water interactions Metal complexes: A:E.121, A:D.152, A:D.152, H2O.1, H2O.1 CA.5: 2 residues within 4Å: Chain A: E.38, D.41 2 PLIP interactions: 2 interactions with chain A Metal complexes: A:E.38, A:D.41

Links

RCSB   PDBe   PDBj   PDBsum   CATH   PLIP

Citation

Guo, Y. et al., Structural basis for distinct ligand-binding and targeting properties of the receptors DC-SIGN and DC-SIGNR. Nat.Struct.Mol.Biol. (2004)

Release Date

2004-06-15

Peptides

C-type lectin DC-SIGNR: A

SMTL:PDB

SMTL Chain Id:
PDB Chain Id:

A
A

C-type lectin DC-SIGNR

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