SMTL ID : 1niv.1

MANNOSE-SPECIFIC AGGLUTININ (LECTIN) FROM SNOWDROP (GALANTHUS NIVALIS) BULBS IN COMPLEX WITH MANNOSE-ALPHA 1,3-METHYL-D-MANNOSE

Coordinates

PDB Format

Method

X-RAY DIFFRACTION 3.00 Å

Oligo State

homo-tetramer

Ligands

6 x MMA- MAN: alpha-D-mannopyranose-(1-3)-methyl alpha-D-mannopyranoside(Non-covalent)

MMA-MAN.1: 7 residues within 4Å: Chain A: Q.57, D.59, N.61, V.63, Y.65, A.74, N.76 5 PLIP interactions: 5 interactions with chain A Hydrogen bonds: A:Q.57, A:Q.57, A:D.59, A:N.61, A:Y.65, A:N.76 MMA-MAN.2: 5 residues within 4Å: Chain A: Q.26, D.28, N.30, Y.34 Chain C: D.37 6 PLIP interactions: 1 interactions with chain C, 5 interactions with chain A Hydrogen bonds: C:D.37, A:Q.26, A:D.28, A:N.30, A:Y.34, A:Y.34 MMA-MAN.3: 5 residues within 4Å: Chain B: Q.26, D.28, N.30, Y.34 Chain D: D.37 6 PLIP interactions: 1 interactions with chain D, 5 interactions with chain B Hydrogen bonds: D:D.37, B:Q.26, B:D.28, B:N.30, B:Y.34, B:Y.34 MMA-MAN.7: 7 residues within 4Å: Chain C: Q.57, D.59, N.61, V.63, Y.65, A.74, N.76 5 PLIP interactions: 5 interactions with chain C Hydrogen bonds: C:Q.57, C:Q.57, C:D.59, C:N.61, C:Y.65, C:N.76 MMA-MAN.8: 5 residues within 4Å: Chain A: D.37 Chain C: Q.26, D.28, N.30, Y.34 6 PLIP interactions: 1 interactions with chain A, 5 interactions with chain C Hydrogen bonds: A:D.37, C:Q.26, C:D.28, C:N.30, C:Y.34, C:Y.34 MMA-MAN.9: 5 residues within 4Å: Chain B: D.37 Chain D: Q.26, D.28, N.30, Y.34 6 PLIP interactions: 1 interactions with chain B, 5 interactions with chain D Hydrogen bonds: B:D.37, D:Q.26, D:D.28, D:N.30, D:Y.34, D:Y.34

6 x MMA: methyl alpha-D-mannopyranoside(Non-covalent)

MMA.4: 9 residues within 4Å: Chain A: Q.89, D.91, N.93, V.95, Y.97 Chain D: N.83, D.100, A.103, H.107 7 PLIP interactions: 3 interactions with chain D, 4 interactions with chain A Hydrogen bonds: D:N.83, D:H.107, A:Q.89, A:N.93, A:Y.97, A:Y.97 Salt bridges: D:H.107 MMA.5: 9 residues within 4Å: Chain B: Q.89, D.91, N.93, V.95, Y.97 Chain C: N.83, D.100, A.103, H.107 7 PLIP interactions: 4 interactions with chain B, 3 interactions with chain C Hydrogen bonds: B:Q.89, B:D.91, B:N.93, B:Y.97, C:N.83, C:H.107 Salt bridges: C:H.107 MMA.6: 7 residues within 4Å: Chain B: Q.57, D.59, N.61, V.63, Y.65, A.74, N.76 6 PLIP interactions: 6 interactions with chain B Hydrogen bonds: B:Q.57, B:D.59, B:N.61, B:Y.65, B:Y.65, B:N.76 MMA.10: 9 residues within 4Å: Chain B: N.83, D.100, A.103, H.107 Chain C: Q.89, D.91, N.93, V.95, Y.97 7 PLIP interactions: 3 interactions with chain B, 4 interactions with chain C Hydrogen bonds: B:N.83, B:H.107, C:Q.89, C:N.93, C:Y.97, C:Y.97 Salt bridges: B:H.107 MMA.11: 9 residues within 4Å: Chain A: N.83, D.100, A.103, H.107 Chain D: Q.89, D.91, N.93, V.95, Y.97 7 PLIP interactions: 3 interactions with chain A, 4 interactions with chain D Hydrogen bonds: A:N.83, A:H.107, D:Q.89, D:D.91, D:N.93, D:Y.97 Salt bridges: A:H.107 MMA.12: 7 residues within 4Å: Chain D: Q.57, D.59, N.61, V.63, Y.65, A.74, N.76 6 PLIP interactions: 6 interactions with chain D Hydrogen bonds: D:Q.57, D:D.59, D:N.61, D:Y.65, D:Y.65, D:N.76

Links

RCSB   PDBe   PDBj   PDBsum   CATH   PLIP

Citation

Hester, G. et al., The mannose-specific bulb lectin from Galanthus nivalis (snowdrop) binds mono- and dimannosides at distinct sites. Structure analysis of refined complexes at 2.3 A and 3.0 A resolution. J.Mol.Biol. (1996)

Release Date

1996-10-14

Peptides

AGGLUTININ: ABCD

SMTL:PDB

SMTL Chain Id:
PDB Chain Id:

A
A

B
C

C
A

D
C

AGGLUTININ

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