SMTL ID : 1ltt.1

LACTOSE BINDING TO HEAT-LABILE ENTEROTOXIN REVEALED BY X-RAY CRYSTALLOGRAPHY

Coordinates

PDB Format

Method

X-RAY DIFFRACTION 2.30 Å

Oligo State

hetero-5-1-1-mer

Ligands

5 x BGC- GAL: beta-D-galactopyranose-(1-4)-beta-D-glucopyranose(Non-covalent)

BGC-GAL.1: 7 residues within 4Å: Chain A: E.51, Q.56, H.57, Q.61, W.88, N.90, K.91 8 PLIP interactions: 8 interactions with chain A Hydrogen bonds: A:Q.56, A:Q.56, A:Q.61, A:Q.61, A:N.90, A:N.90, A:K.91, A:K.91 Water bridges: A:Q.61, A:N.90, A:N.14 BGC-GAL.2: 9 residues within 4Å: Chain B: R.13, E.51, Q.56, H.57, I.58, Q.61, W.88, N.90, K.91 8 PLIP interactions: 8 interactions with chain B Hydrogen bonds: B:R.13, B:Q.56, B:Q.56, B:Q.56, B:Q.61, B:Q.61, B:N.90, B:N.90, B:K.91 Water bridges: B:I.58, B:Q.61, B:Q.61, B:N.90, B:E.51, B:I.58 BGC-GAL.3: 7 residues within 4Å: Chain C: E.51, Q.56, H.57, Q.61, W.88, N.90, K.91 7 PLIP interactions: 7 interactions with chain C Water bridges: C:Q.56, C:Q.61, C:Q.61, C:E.51 Hydrogen bonds: C:E.51, C:Q.61, C:Q.61, C:N.90, C:N.90, C:K.91 BGC-GAL.4: 7 residues within 4Å: Chain D: E.51, Q.56, H.57, Q.61, W.88, N.90, K.91 8 PLIP interactions: 7 interactions with chain D, 1 interactions with chain E Water bridges: D:R.13, D:R.13, D:R.13, D:N.14, E:G.33 Hydrogen bonds: D:Q.56, D:Q.61, D:Q.61, D:N.90, D:N.90, D:K.91, D:K.91 BGC-GAL.5: 7 residues within 4Å: Chain E: E.51, Q.56, H.57, Q.61, W.88, N.90, K.91 7 PLIP interactions: 5 interactions with chain E, 2 interactions with chain A Hydrogen bonds: E:Q.56, E:Q.61, E:Q.61, E:N.90, E:N.90, E:K.91 Water bridges: E:Q.61, A:K.34, A:K.34

Links

RCSB   PDBe   PDBj   PDBsum   CATH   PLIP

Citation

Sixma, T.K. et al., Lactose binding to heat-labile enterotoxin revealed by X-ray crystallography. Nature (1992)

Release Date

1994-01-31

Peptides

HEAT-LABILE ENTEROTOXIN, SUBUNIT B: ABCDE
HEAT-LABILE ENTEROTOXIN, SUBUNIT A: F
HEAT-LABILE ENTEROTOXIN, SUBUNIT A: G

SMTL:PDB

SMTL Chain Id:
PDB Chain Id:

A
D

B
E

C
F

D
G

E
H

F
A

G
C

HEAT-LABILE ENTEROTOXIN, SUBUNIT B

HEAT-LABILE ENTEROTOXIN, SUBUNIT A

HEAT-LABILE ENTEROTOXIN, SUBUNIT A

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