SMTL ID : 1lta.1

2.2 ANGSTROMS CRYSTAL STRUCTURE OF E. COLI HEAT-LABILE ENTEROTOXIN (LT) WITH BOUND GALACTOSE

Coordinates

PDB Format

Method

X-RAY DIFFRACTION 2.20 Å

Oligo State

hetero-5-1-1-mer

Ligands

5 x GAL: beta-D-galactopyranose(Non-covalent)

GAL.1: 7 residues within 4Å: Chain A: E.51, Q.56, H.57, Q.61, W.88, N.90, K.91 9 PLIP interactions: 9 interactions with chain A Hydrogen bonds: A:Q.56, A:Q.61, A:Q.61, A:N.90, A:N.90, A:K.91, A:K.91 Water bridges: A:N.14, A:I.58 GAL.2: 7 residues within 4Å: Chain B: E.51, Q.56, H.57, Q.61, W.88, N.90, K.91 9 PLIP interactions: 8 interactions with chain B, 1 interactions with chain C Hydrogen bonds: B:Q.56, B:Q.61, B:Q.61, B:N.90, B:N.90, B:K.91 Water bridges: B:S.95, C:G.33 Salt bridges: B:K.91 GAL.3: 7 residues within 4Å: Chain C: E.51, Q.56, H.57, Q.61, W.88, N.90, K.91 10 PLIP interactions: 9 interactions with chain C, 1 interactions with chain D Hydrogen bonds: C:Q.56, C:Q.61, C:Q.61, C:N.90, C:N.90, C:K.91, C:K.91 Water bridges: C:E.51, D:G.33 Salt bridges: C:K.91 GAL.4: 7 residues within 4Å: Chain D: E.51, Q.56, H.57, Q.61, W.88, N.90, K.91 7 PLIP interactions: 7 interactions with chain D Hydrogen bonds: D:E.51, D:Q.56, D:Q.61, D:Q.61, D:N.90, D:N.90, D:K.91 GAL.5: 7 residues within 4Å: Chain E: E.51, Q.56, H.57, Q.61, W.88, N.90, K.91 6 PLIP interactions: 6 interactions with chain E Hydrogen bonds: E:Q.61, E:Q.61, E:N.90, E:N.90, E:K.91 Salt bridges: E:K.91

Links

RCSB   PDBe   PDBj   PDBsum   CATH   PLIP

Citation

Merritt, E.A. et al., Galactose-binding site in Escherichia coli heat-labile enterotoxin (LT) and cholera toxin (CT). Mol.Microbiol. (1994)

Release Date

1994-01-31

Peptides

HEAT-LABILE ENTEROTOXIN, SUBUNIT B: ABCDE
HEAT-LABILE ENTEROTOXIN, SUBUNIT A: F
HEAT-LABILE ENTEROTOXIN, SUBUNIT A: G

SMTL:PDB

SMTL Chain Id:
PDB Chain Id:

A
D

B
E

C
F

D
G

E
H

F
A

G
C

HEAT-LABILE ENTEROTOXIN, SUBUNIT B

HEAT-LABILE ENTEROTOXIN, SUBUNIT A

HEAT-LABILE ENTEROTOXIN, SUBUNIT A

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