SMTL ID : 1iuc.1

Fucose-specific lectin from Aleuria aurantia with three ligands

Coordinates

PDB Format

Method

X-RAY DIFFRACTION 2.24 Å

Oligo State

homo-dimer

Ligands

4 x FUL: beta-L-fucopyranose(Non-covalent)

FUL.1: 8 residues within 4Å: Chain A: R.77, E.89, G.100, Q.101, L.102, I.130, W.149, W.153 7 PLIP interactions: 7 interactions with chain A Hydrophobic interactions: A:I.130, A:W.149 Hydrogen bonds: A:E.89, A:Q.101, A:L.102 Water bridges: A:T.99 Salt bridges: A:R.77 FUL.2: 6 residues within 4Å: Chain A: R.24, E.36, I.74, I.76, Y.92, W.97 9 PLIP interactions: 9 interactions with chain A Hydrophobic interactions: A:I.74, A:I.76, A:Y.92 Hydrogen bonds: A:E.36 Water bridges: A:R.24, A:R.24, A:E.36, A:E.36 Salt bridges: A:R.24 FUL.5: 8 residues within 4Å: Chain B: R.77, E.89, G.100, Q.101, L.102, I.130, W.149, W.153 7 PLIP interactions: 7 interactions with chain B Hydrophobic interactions: B:I.130, B:W.149 Hydrogen bonds: B:E.89, B:Q.101, B:L.102 Water bridges: B:T.99 Salt bridges: B:R.77 FUL.6: 6 residues within 4Å: Chain B: R.24, E.36, I.74, I.76, Y.92, W.97 9 PLIP interactions: 9 interactions with chain B Hydrophobic interactions: B:I.74, B:I.76, B:Y.92 Hydrogen bonds: B:E.36 Water bridges: B:R.24, B:R.24, B:E.36, B:Q.38 Salt bridges: B:R.24

2 x FUC: alpha-L-fucopyranose(Non-covalent)

FUC.3: 10 residues within 4Å: Chain A: I.173, R.179, E.191, Y.200, G.202, G.203, F.204, I.225, Y.241, W.245 7 PLIP interactions: 7 interactions with chain A Hydrophobic interactions: A:I.173, A:Y.241 Hydrogen bonds: A:R.179, A:E.191, A:G.203, A:F.204 Salt bridges: A:R.179 FUC.7: 10 residues within 4Å: Chain B: I.173, R.179, E.191, Y.200, G.202, G.203, F.204, I.225, Y.241, W.245 7 PLIP interactions: 7 interactions with chain B Hydrophobic interactions: B:I.173, B:Y.241 Hydrogen bonds: B:R.179, B:E.191, B:G.203, B:F.204 Salt bridges: B:R.179

2 x SO4: SULFATE ION(Non-functional Binders)

SO4.4: 5 residues within 4Å: Chain A: K.136, S.137, S.142, S.143, H.145 5 PLIP interactions: 5 interactions with chain A Hydrogen bonds: A:S.137, A:S.137, A:S.143 Water bridges: A:K.136 Salt bridges: A:H.145 SO4.8: 5 residues within 4Å: Chain B: K.136, S.137, S.142, S.143, H.145 5 PLIP interactions: 5 interactions with chain B Hydrogen bonds: B:S.137, B:S.137, B:S.143 Water bridges: B:K.136 Salt bridges: B:H.145

Links

RCSB   PDBe   PDBj   PDBsum   CATH   PLIP

Citation

Fujihashi, M. et al., Crystal Structure of Fucose-Specific Lectin from Aleuria aurantia Binding Ligands at Three of Its Five Sugar Recognition Sites. Biochemistry (2003)

Release Date

2003-09-30

Peptides

Fucose-specific lectin: AB

SMTL:PDB

SMTL Chain Id:
PDB Chain Id:

A
A

B
A

Fucose-specific lectin

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