SMTL ID : 1esl.1

INSIGHT INTO E-SELECTIN(SLASH)LIGAND INTERACTION FROM THE CRYSTAL STRUCTURE AND MUTAGENESIS OF THE LEC(SLASH)EGF DOMAINS

Coordinates

PDB Format

Method

X-RAY DIFFRACTION 2.00 Å

Oligo State

monomer

Ligands

3 x CA: CALCIUM ION(Non-covalent)

CA.1: 5 residues within 4Å: Chain A: E.80, N.82, N.83, N.105, D.106 5 PLIP interactions: 3 interactions with chain A, 2 Ligand-Water interactions Metal complexes: A:E.80, A:D.106, A:D.106, H2O.2, H2O.4 CA.2: 2 residues within 4Å: Chain A: E.33, E.36 4 PLIP interactions: 2 interactions with chain A, 2 Ligand-Water interactions Metal complexes: A:E.33, A:E.36, H2O.2, H2O.4 CA.3: 2 residues within 4Å: Chain A: Q.20, Y.23 5 PLIP interactions: 2 interactions with chain A, 3 Ligand-Water interactions Metal complexes: A:Q.20, A:Y.23, H2O.1, H2O.1, H2O.4

2 x CL: CHLORIDE ION(Non-functional Binders)

CL.4: 5 residues within 4Å: Chain A: W.1, S.2, A.121, N.138, N.139 Ligand excluded by PLIP CL.5: 4 residues within 4Å: Chain A: S.126, C.127, Y.140, K.152 Ligand excluded by PLIP

Links

RCSB   PDBe   PDBj   PDBsum   CATH   PLIP

Citation

Graves, B.J. et al., Insight into E-selectin/ligand interaction from the crystal structure and mutagenesis of the lec/EGF domains. Nature (1994)

Release Date

1994-08-31

Peptides

HUMAN E-SELECTIN: A

SMTL:PDB

SMTL Chain Id:
PDB Chain Id:

A
A

HUMAN E-SELECTIN